Bacteriophage sensitivity of opportunistic microbiota in children with gut dysbiosis

Aim. As the activity of bacteriophages is species- and strain-specific, it necessary to study bacteriophage sensitivity in distinct geographic regions with various disease patterns. Here, we aimed lytic specific commercially available against Klebsiella spp., Proteus spp. , Staphylococcus aureus isolated from intestines children gut dysbiosis. Materials Methods. Bacteriophage was assessed 315 opportunistic microorganisms (125 strains, 120 70 strains) intestinal microbiota 300 < 4 years age preparations were produced by Microgen (Russian Federation). The studied a drip method on Muller-Hinton medium calculating area bacterial culture lysis. Results. We found low (37.5% sensitive (41.4% bacteriophages, albeit there considerable differences between species ( pneumoniae 56.7% strains; oxytoca 18.3% p = 0.03) vulgaris 52.0% mirabilis 35.6% 0.04). Nevertheless, considerably higher (78.4%). In addition, reduced along increasing severity Conclusion. dysbiosis have bacteriophages. positively correlated